CORE SHELL NANOPARTICLE APPLICATIONS FREE

Only a few approaches were able to achieve both of these effects Therefore, to ensure sufficient drug levels in the pathologicalĬells, drug delivery systems have to enter the target cells andĮfficiently release the drug molecules into the targeted cellĭecade, a number of studies have investigated methods of enhancingĬellular uptake and achieving rapid intracellular release however, Interfering RNAs, have to be delivered and released into specificĬellular compartments, such as the cytoplasm of pathological cells. Many drugs, including small molecule drugs, proteins and small Inefficient drug release and cellular uptake, which largelyĬompromises the drug treatment benefits in the clinic ( 3). Merits, the majority of nanoscale drug delivery systems exhibit Pharmacological profiles and drug tolerance and prolonged Several advantages, including decreased adverse effects, improved Microparticles, these nanoscale drug formulations have demonstrated

CORE SHELL NANOPARTICLE APPLICATIONS FREE

Compared with other traditionalĪpproaches, such as injection of free drug solution or drug loaded Nanoparticles, liposomes and nanogels, have been developed for Several nanoscale drug delivery systems, including polymeric Is still the leading cause of death worldwide, responsible for ~1/4 In conclusion, with enhanced cellular uptake and light‑triggered intracellular release, CCS significantly enhanced the therapeutic effects of doxorubicin, and may serve as a promising avenue for intracellular drug delivery.ĭespite numerous advances in biotechnology, cancer Finally, the cytotoxicity of doxorubicin towards MDA‑MB‑231 cells was significantly increased by CCS delivery upon pulsed laser irradiation. The released 6‑CF was evenly distributed throughout the entire cytosol and nucleus. Nanosecond pulsed laser irradiation (700 nm 100 mJ/cm2 5 pulses) rapidly triggered the intracellular release of a fluorescent dye, 6‑carboxyfluorescein (6‑CF), from CCS and CS trapped in endolysosomes. The results demonstrated that the uptake of CCS in HA receptor‑expressing MDA‑MB‑231R cells was significantly enhanced compared with unmodified CS. HA modification enhances the endocytosis of the nanoparticles by HA receptor‑expressing cells, while the plasmonic properties of gold nanoparticles enable their light‑triggered drug release.

Light‑responsive core‑shell nanoparticles, i.e., gold nanoparticles‑coated liposomes (CS), were prepared and further modified with hyaluronic acid (HA) (CCS). In the present study, a novel corona core‑shell nanoparticle was proposed for enhanced cellular uptake and light‑responsive intracellular release. Drugs, including small molecule anticancer drugs, have to be delivered and released into the cytoplasm or nucleus in order to elicit a therapeutic effect.

Core shell nanoparticle applications